Background: Nitrogen containing bisphosphonates such as zoledronic acid (ZA) are known to contain certain anti-cancer properties. These have been investigated in the past in various cancers such as breast, prostate and colon. ZA in particular has shown promising results in pre-clinical studies. We … More
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Recent Articles
Increased Risks Of Lower-Limb Amputations For Farxiga And Jardiance
During late August a presentation at the 2018 European Society of Cardiology Congress in Munich, Germany included evidence that the SGLT-2 inhibitors Invokana, Jardiance, and Farxiga all are associated with twofold increases for lower-limb amputations when compared to GLP-1 receptor agonists … More
Tradjenta Associated With Bullous Pemphigoid Skin Disease Side Effect
Some recent medical journal articles present new findings relevant to Tradjenta-induced bullous pemphigoid (BP), which would be a skin disease side effect. Tradjenta (linagliptin), which is part of the dipeptidyl peptidase 4 (DPP-4) inhibitors class of type 2 diabetes drugs. The first medical … More
Early Signs of Efficacy Seen With Mesothelin CAR T-Cell Therapy
Mesothelin-targeted chimeric antigen receptor (CAR) T-cell therapy has shown early evidence of efficacy in a phase I trial of patients with malignant pleural disease and mesothelioma, non–small cell lung cancer, or breast cancer (NCT02414269). Additionally, significant responses were seen in … More
It’s time for the EPA to ban asbestos once and for all
Nearly 40,000 Americans die from preventable asbestos-caused diseases every year, yet the Environmental Protection Agency (EPA) still hasn’t banned this toxic substance. Asbestos was once marketed as a “miracle mineral” for its flame-resistance, strength and flexibility to use in construction, … More
Invokana, Jardiance, And Farxiga Have Increased Risks Of Amputations
Sodium-glucose cotransporter 2 inhibitors (SGLT-2 inhibitors) such as Invokana, Jardiance, and Farxiga have a higher risk of leg, feet, and toe amputations drug-class side effect when compared to older diabetes drugs such as sulfonylureas, metformin, and thiazolidinediones. This finding was … More