Carefully selected patients with malignant pleural mesothelioma benefited from a surgery-based treatment modality, according to results from a propensity score matching analysis published in Journal of Clinical Oncology.Previous studies investigated whether surgery may extend survival among patients with malignant pleural mesothelioma; however, limitations exist — such as poor patient accrual and higher than expected mortality rates — and it is unclear if these results are generalizable.“As such, additional efforts to show the efficacy of surgical therapy for mesothelioma are needed,” Boris Sepesi, MD, FACS, assistant professor in the department of thoracic and cardiovascular surgery at The University of Texas MD Anderson Cancer Center, and colleagues wrote. “For such a disease process with a limited incidence, complex therapy and high mortality as with mesothelioma, a well-constructed database study that pools outcomes from multiple institutions can potentially offer more detailed results.”
Sepesi and colleagues used the National Cancer Data Base to identify patients with microscopically proven malignant pleural mesothelioma. Researchers evaluated survival following cancer-directed surgery, as well as surgery interaction with chemotherapy or radiation therapy.[Article continues at original source]
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