Diffuse malignant mesothelioma of the pleura (MPM) is a highly aggressive tumour that typically is associated with short survival. CD70 and CD27 belong to the tumour necrosis factor (TNF) and the TNF receptor (TNFR) superfamily, respectively. Under physiological conditions, the tightly regulated interaction between CD70 and CD27 plays a co-stimulatory role in promoting T-cell expansion and differentiation through the NF?B pathway. Aberrantly high CD70 expression has been documented in haematological and solid malignancies in association with immune evasion in malignant cells. In this study, 172 well-characterized primary diffuse MPM tumours including epithelioid (n?=?145), biphasic (n?=?15), and sarcomatoid (n?=?12) histotypes were evaluated immunohistochemically for CD70, CD27, CD3, CD4, CD8, CD56, PDCD1 (PD-1) and FOXP3 expression. Twenty percent (34/172) of the mesothelioma cells expressed CD70 on the cell membrane. Overall survival was significantly decreased in the cohort of patients with CD70-expressing tumour cells (P <?0.01). Patients with MPM containing higher number of CD3+ (P <?0.01), CD4+ (P <?0.01), CD8+ (P <?0.01), or FOXP3+ (P <?0.01) tumour-infiltrating lymphoid cells (TILs) showed significantly worse clinical outcomes….[Article continues at original source]
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